WNT2B, Wnt family member 2B, 7482

N. diseases: 65; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.010 Biomarker group LHGDN WNT2B: comparative integromics and clinical applications (Review). 16273293 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 AlteredExpression disease LHGDN Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. 12072409 2002
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.040 AlteredExpression disease BEFREE We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro. 25297925 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE Using normal mucosa, the association of ACSL5 and Wnt2B was seen, but in intestinal neoplasias the mechanism was only rudimentarily observed. 25356045 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.010 AlteredExpression disease BEFREE Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. 29108989 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.010 AlteredExpression disease BEFREE Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. 29108989 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.010 AlteredExpression disease BEFREE Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. 29108989 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.010 Biomarker disease BEFREE Twenty-four genes are significantly different from adult, and 13 genes might be developing hippocampus-specific candidate genes, including wnt2b and some Alzheimer's disease-related genes. 12271469 2002
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure
0.100 GeneticVariation phenotype GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker phenotype BEFREE These results suggest that the Wnt-13 gene may be involved in normal human development or differentiation as well as in human carcinogenesis. 8761309 1996
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 Biomarker group BEFREE These findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases. 28638086 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 Biomarker disease BEFREE These findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases. 28638086 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 Biomarker phenotype BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 Biomarker disease BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.010 Biomarker disease BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.010 Biomarker disease BEFREE These data suggest that Wnt2B indeed plays an important role in ovarian cancer metastasis and drug resistance. 22635028 2012
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.040 Biomarker disease BEFREE The target gene of miR-185-3p, Wnt family member 2B (<i>WNT2B)</i> was silenced in 5-8F cells using siRNA in order to investigate its function in NPC. 28454443 2017
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.020 Biomarker disease BEFREE The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B. 29917177 2018
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.010 Biomarker group BEFREE The results showed that the expression of Wnt5a (41/45), Wnt10b (37/45), and Wnt13 (35/45) were found in brain tumors, whereas Wnt1 (6/45) was shown to be less related. 12049819 2002
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 Biomarker phenotype BEFREE The results of the present study indicate that miR-185-3p mediates the invasion and metastasis of NPC by targeting <i>WNT2B in vitro</i>. 28454443 2017
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects
0.010 AlteredExpression group BEFREE The results demonstrated that the transcriptional activities of Wnt2b and Wnt7b were abnormally upregulated in mouse fetuses with NTDs and, in the GC‑rich promoters of these genes, histone 3 lysine 4 (H3K4) acetylation was enriched, whereas H3K27 trimethylation was reduced. 26548512 2016
CUI: C0428883
Disease: Diastolic blood pressure
Diastolic blood pressure
0.100 GeneticVariation phenotype GWASCAT The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 27618452 2016
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure
0.100 GeneticVariation phenotype GWASCAT The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 27618452 2016
CUI: C0034951
Disease: Refractive Errors
Refractive Errors
0.010 AlteredExpression group BEFREE The amounts of Wnt2b, Fzd5 and β-catenin mRNA and protein were significantly greater in form-deprived myopia eyes than in control eyes.DKK-1 (antagonist) reduced the myopic shift in refractive error and increase in axial elongation, whereas Norrin had the opposite effect in FDM eyes. 24755605 2014
CUI: C0027092
Disease: Myopia
Myopia
0.010 AlteredExpression disease BEFREE The amounts of Wnt2b, Fzd5 and β-catenin mRNA and protein were significantly greater in form-deprived myopia eyes than in control eyes.DKK-1 (antagonist) reduced the myopic shift in refractive error and increase in axial elongation, whereas Norrin had the opposite effect in FDM eyes. 24755605 2014